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Long-term effects of adequate Vitamin B12 levels include better red blood cell production, improved neurological function, and enhanced metabolic health

It may be possible to extend the rapidly occurring beneficial cytoprotective effect of these agents and to use them to prevent ischemic colitis lesions, in which specific activation of the collateral circulation can circumvent obstructions and reestablish the continuity of blood flow

(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1 (Ero1), leading to ER stress and subsequent inflammation

Given the various existing regimens, each with its advantages and disadvantages, future studies should compare these regimens with other strategies to provide a more comprehensive clinical reference