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ROS production is exacerbated by reduced protein synthesis, an increase of protein folding capacity, and removal of misfolded proteins, resulting in the accumulation of iron, all of which provide the necessary conditions for ferroptosis (Han et al., 2013)

Lipofuscin, advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs), amyloid beta peptide (A-40), interleukin 1 beta (IL-1), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-), and interleukin 10 (IL-10) levels were determined using ELISA kits from Huijia Biotechnology (Xiamen, China)

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