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In conclusion, UPS has an important role in the development of AKI, mostly by NF-B, ferroptosis, oxidative stress, lipid homeostasis, and KLF4/ITCH/LATS1/YAP pathway

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30,33 In chronic inflammation patients, the effects of iron deficiency may be particularly severe, exacerbating the underlying disease state and leading to accelerated clinical deterioration

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Interleukin-6 receptor inhibition in Covid-19 Cooling the Inflammatory Soup

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