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Recently, the protective role of the mitochondrial unfolded protein response (UPR mt ) in cardiac pathophysiology has drawn increasing attention

However, adipose-ARKO resulted in increased mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1), uncoupling protein 2 (UCP2), and fatty acid mitochondrial transporter (CPT1) in epididymal WAT, suggesting that adipose-specific AR may be involved in lipid mobilization and fatty acid metabolism

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These findings suggest that the upregulated expression of adipogenic, lipid synthesis, and storage-related genes in the 50W group increases phosphatidylcholine content and reduces acylcarnitine levels in muscle tissues