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The optimal dosing regimens and duration of supplementation are also important aspects to be further explored regarding the risk versus curative benefits

Ward HA et al (2010) Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and NutritionNorfolk in relation to phytoestrogen intake derived from an improved database

These factors notwithstanding, the problem of DILI attributable to HDS remains an important concern for Americans, as HDS are the second most common cause of DILI among enrollees into the DILIN

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