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When evaluating the binding energy of isoxazole 1 using this method, we found a much smaller effect (8.3 kcal/mol for Cn Acs1 vs 8.1 kcal/mol for Cn Ca Acs1), but one that still showed reduced preference for the Ca Acs2 binding site residues

Here, the reduction in PDHC activity is attributed to the reduced efficiency of PDK4 in the presence of elevated pyruvate concentrations [163]

Additionally, to the cell wall, RBOHs are also expressed in vacuoles, endoplasmic reticulum, nucleus, and mitochondria (Mittler, 2017)

T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome, Springer Science and Business Media LLC, (2023)