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Recent studies indicate that PHGDH expression is reduced by 40-50% in 1p/19q-codeleted gliomas compared to non-codeleted gliomas, suggesting these gliomas have selective vulnerability to serine and glutathione depletion (103)

The results showed no histological alterations, indicative of the high biocompatibility and biosafety

Other systemic strategies exert comparable effects: regular exercise reduces circulating glucose levels at the expense of tumors 204 , and adrenergic activation in brown adipose tissue suppresses tumor growth by increasing host glucose utilization 205