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While its safety profile was consistently favorable, the largest Phase IIb trial failed to show statistical significance for weight loss, and commercial development was halted in 2007.[2] Despite this, interest in AOD-9604 has continued in the compounding pharmacy and integrative medicine space, particularly given its safety data, its lack of IGF-1 stimulation, and emerging research around joint health

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Yoshida, K., Ito, D., & Kondo, T

This single-nucleotide polymorphism, which encodes either alanine or threonine at position 391, is also associated with altered microbiome composition, indicating a potential microbiome-driven role for ZIP8 in Crohns disease (129)