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Secretome engineering is an emerging frontier: PD-MSCs primed to secrete high hepatocyte-growth-factor engage Wnt/-catenin signalling to tighten endothelial barriers and foster follicular growth [183], while an estrogen-responsive PD-MSC secretome rescues cyclophosphamide-induced POI, restores circadian clock genes and curbs granulosa-cell apoptosis, suggesting cell-free formulations could combine ovarian repair with systemic chronoprotection [20]

ROS reactive oxygen species RNS reactive nitrogen species the thiol (-SH) moiety is capable of post translational protein modifications that may disable thermodynamically less stable viral proteins synthesized during infections

Our understanding of the pathogenesis of IPF have significantly improved in the past decade

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