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Infusion of Ang IV directly in renal arteries was reported to increase renal CBF in anesthetized rats as measured by laser Doppler flowmetry, 60, 126 an effect blocked by the specific AT 4 receptor antagonist, Divalinal-Ang IV, but not by selective AT 1 and AT 2 receptor antagonists

Its ability to promote collagen production and reduce inflammation makes it an attractive ingredient in cosmetic and dermatological formulations

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