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This discrepancy might be attributed to their difference in membrane permeability, considering that SMP2 (calculated octanol-water partition coefficient (cLog P ) = 1.50) diffused across the plasma membrane more easily than excessively hydrophilic SMP1 (cLog P = 2.78)

Another example is Receptor Grade IGF-1 LR3, which researchers speculate exhibits an increased affinity and anabolic potential while binding less to IGF-1 binding proteins (IGF-1BPs)