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In brief, IsoNet includes four major steps: (1) annotation of labeled metabolites

Certain probiotic microorganisms synthesize organic acid and volatile fatty acids (lactic, butyric, acetic, and propionic acid), significantly reducing the pH of the gastrointestinal lumen and subsequently arresting the growth of opportunistic pathogenic organisms (Ma et al., 2019)

Selected mouse studies did not find a significant reduction in food intake

Furthermore, HDL drives conversion to the anti-inflammatory M2 macrophages which have enhanced efferocytosis ability compared to inflammatory M1 macrophages (56,208) leading to increased plaque stability