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NMO is mainly caused by auto-anti-AQP4 antibodies 282 that initially attack astrocytic endfeet, 283 leading to complement-mediated lysis and destruction of the glial limitans and astrocyte degeneration, which in turn cause the other pathophysiological sequalae (Fig

For the individuals with ASD identified from 19902019, the lifetime social (medical, educational, productivity, and care) cost for the US was estimated to be more than $7 trillion in 2019 dollars [80]

doi: 10.1016/j.jinorgbio.2017.10.006 89 Thi Thu NguyenT.MiyagiS.TsujiguchiH.KambayashiY.HaraA.NakamuraH.et al

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