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It is known that there is no detectable mRNA expression of pro-inflammatory cytokines in normal myocardial tissue, 37 but once cardiac injury sets in (such as with an MI), the intracardiac expression of IL-6, TNF- and IFN- mRNA expression possibly mediate the events of remodeling in the myocardium as reported earlier

If symptoms recur early, bring doses closer together and reassess cofactors