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The mechanisms by which IGF-I reverses and/or prevents microvascular rarefaction and improves tissue blood supply are likely multifaceted, and may involve, among others: 1) Apoptosis, since IGF-I inhibits oxidative stress-induced apoptosis by preserving the functional integrity of the mitochondria[56, 290]

The LSMBO team develops innovative methodologies in chromatography, mass spectrometry (MS) and bioinformatics for : Functional proteomic analysis for the identification and quantification of thousands of proteins in complex biological matrices (sample preparation, targeted (PRM) and global (DIA) quantitative LC-MS/MS analysis, statistical analysis and integration of multi-omics data)

A written informed consent form was obtained from all participants but a waiver of consent was obtained for those admitted to the ICU