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Animal and clinical studies have shown that genetic ablation, disease-related impairment, or dietary depletion of creatine leads to phenotypic manifestations characterized by diminished muscle contractility, cognitive dysfunction, and increased susceptibility to metabolic stress [13,14,15,16]

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These practical definitions of temperature generally rely on fixing the values of certain reference points based on careful measurements of their thermodynamic temperatures, and then specifying a way of interpolating between them

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