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Increased VEGF increased ocular permeability and neovascularization and accelerated the development of diabetic retinopathy [110]

Upregulation of HO-1 with cobalt metalloporphyrin protoporphyrin IX (CoPP) in hRSV-infected mice significantly reduced disease-related body weight loss and induced an upregulation of IFN-/ in the lungs, indicating that HO-1 plays an important role in the development of the antiviral type I IFN response in the airways (106)