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The utility of this stimuli-responsive platform is demonstrated through two complementary in vivo applications: tumor-targeted prodrug activation triggered by the reductive tumor microenvironment in a 4T1 breast cancer model, and repeatable, on-demand local anesthesia controlled by 405 nm light

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Subsequent cell- and animal- based assays confirmed that Al 2 O 3 NPs caused mitochondria-dependent apoptosis and oxidative stress either in vitro or in vivo, which were consistent with the trends of gene regulation