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Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS

At the immune cell level, melatonin enhances CD4 + /CD8 + T cell proliferation and antigen responsiveness, modulates the Treg/Th1/Th2 balance, promotes macrophage polarization toward the anti-inflammatory M2 phenotype, and augments NK cell cytotoxicity