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However, the presence of trisomic genes also affects the expression of disomic genes, which in turn may gain aberrant expression and contribute to several clinical manifestations

Nat Biotechnol 29: 449-452

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia

As highlighted by Adegbola, the gut microbiome plays a critical role in host amino acid metabolism, and dysbiosis in Crohns disease can significantly influence microbial production or consumption of key amino acids, including tryptophan, branched-chain amino acids, and those involved in sulfur metabolism