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It produces worse side effects, more discontinuations, and often slower progress because severe GI symptoms prevent adequate nutrition and hydration

The mechanisms involved are complex, involving oxidative stress and apoptosis, endothelial dysfunction and other mechanisms, and are closely related to pre-existing cardiovascular health, type of drugs, total dosages and combinations of treatments (14)

In a head-to-head trial against a full-strength GLP-1 drug, tirzepatide reduced food craving without changing measured restraint. Slower stomach emptying also makes smaller portions feel filling for longer. People whose eating was driven by stress, reward, or constant mental effort often describe the quiet as relief

Im seeing the same thing as you. And we were amazed