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A genome-wide RNA interference screen revealed siRNAs targeting CARS (cysteinyl-tRNA synthetase) as robust genetic suppressors of erastin-induced ferroptosis [37]

mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT

Although the precise mechanisms underlying KDs effects in PD remain incompletely understood, evidence suggests that the diet can modulate glucose utilization in the brain, neurotransmitter metabolism, insulin signaling, oxidative stress, neuroinflammation, and ion channel activity, particularly potassium channels [20]

We further tested whether the methylation of UBE2m affects NEDD4 neddylation using exogenous and endogenous assays