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Rev-erb has shown neuroprotective properties in Parkinsons disease, as the loss of its rhythmicity in the substantia nigra of affected patients is associated with exacerbated microglial activation and increased inflammatory markers, conditions that are attenuated following pharmacological reactivation of Rev-erb (Kou et al., 2022)

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Melatonin helps control the bodys natural rhythms by acting on a part of the brain called the SCN