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Uric Acid Production as a Target of Therapy in Patients With Gout In the catabolism of purines, uric acid generation by the enzyme xanthine oxidase (that also has xanthine dehydrogenase activity) ( Figure 1 - 2 ) highlights the key therapeutic mechanisms of action of the xanthine oxidase inhibitors allopurinol and febuxostat ( Pharmacologic Urate-Lowering Therapy )

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Rho Signaling Pathways As discussed earlier, the activity of Rho GTPases is tightly regulated by various GEF and GAP proteins (Govek et al., 2005)