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Abstract Human thioredoxin (TRX) was first identified in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and is associated with the pathophysiology of retroviral infections

Cancers (Basel) 14:312

Poor sleep, high stress and heavy alcohol intake can increase oxidative burden

These factors may lead to hyperactive neurological responses, releasing a cascade of signals that alter cerebral blood vessel dynamics and neurotransmitter levels, such as serotonin and CGRP, leading to the inflammation and pain characteristic of a migraine