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Furthermore, kynurenine stimulates AHR in TAMs, promoting the expression levels of the chemokine receptor CC motif chemokine receptor 2 (CCR2) and increasing MDSCs recruitment via the CCR2-CCL2 (CC motif chemokine ligand 2) axis [121]

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Gallbladder events rise modestly, especially with rapid loss. Less common signals include skin dysesthesia, which is now on the label, and a small thyroid-cancer association in two population studies with a tiny absolute event rate. Depression and suicidality remain unproven

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