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Human lumbar vertebrae are required to withstand pressure from more than 50% of the body weight that is further influenced by our upright posture, whereas the spine of quadrupeds, of which most models are based on, does not bear such vertical pressure in the resting state

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Gene transfer of IGF-1 increased expression of antifibrogenic molecules and reduced expression of profibrogenic factors to relieve the cirrhotic liver animal models 15