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doi:10.1093/carcin/23.10.1721

F., Cox, J., Deek, S

Nuclear receptor coactivator 4 (NCOA4) is a selective carrier receptor that can perform selective autophagy of ferritin (ferritinophagy) when intracellular iron levels are low so that iron is released (Ling et al., 2017)

Reactive metabolites from lipid peroxidation disrupt essential cellular structures, initiating cell death and DAMP releasea process further amplified by antioxidant depletion and exemplified in SLE, where neutrophils undergo ferroptosis and NETosis, activating TLR-dependent ROS generation that propagates inflammatory tissue injury (76, 87, 113115)