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Intranasal bacterial therapeutics reduce colonization by the respiratory pathogen Mannheimia haemolytica in dairy calves

doi: 10.3389/fneur.2024.1380353 12

Using DNA methylation data of postmortem DLPFC brain from 468 individuals [20], we found CpG sites scattered around CYP2D6 are significantly interacted with both functional SNPs (e.g., rs133377) and chromatin (e.g., peak16933) (Table S8), implying they function together to regulate CYP2D6 gene transcription