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Optimal timing involves fasted-state administration (06:0009:00) when beta-3 receptor sensitivity peaks, ideally 3045 minutes before moderate-intensity aerobic exercise to ensure mobilised fatty acids are oxidised rather than re-esterified

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(5) evidence neuroprotection especially against neuroinflammation, oxidative stress-induced damage and decreased cerebral blood flow

The cycle length at our Doral clinic is typically 8 to 12 weeks for musculoskeletal indications and 4 to 8 weeks for gut health, with a structured off-cycle period before reassessment