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Another study using well-differentiated primary hBECs from a COPD cohort at an airliquid interface (ALI) found that basolateral treatment with NAC following DEP exposure did not provide any significant therapeutic effects, but did show trends in reducing IL-8 secretion and antioxidant gene expression [54]

M.KangN.BienenstockJ.FosterJ

Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers ( For this reason, many studies have been conducted on the best methods to increase intracellular and intramitochondrial levels of GSH

Brown NS, Bicknell R