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[DOI] [PMC free article] [PubMed] [Google Scholar] Siedlinski M, Postma DS, van Diemen CC, Blokstra A, Smit HA, Boezen HM

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Although the nanoparticle drug delivery system was not initially designed for LDL-receptor-mediated brain targeting, it was later found that apolipoprotein E would be absorbed on the polysorbate 80 coated nanoparticles upon incubation of the nanoparticles with human plasma resulting in LDL-receptor mediated BBB crossing