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Background: Wilson Disease (WD) is a rare disorder caused by mutations in the ATP7B gene (encodes transporter protein to regulate copper levels) that cause a toxic buildup of copper in the liver, brain, and other organs and can result in liver disease, neurological symptoms, and psychiatric behavioral disorders

229 In osteoporosis, MSCs tend to favor adipogenic differentiation, which reduces bone formation and increases fat accumulation within the bone marrow, thereby exacerbating bone loss and increasing the risk of fractures

Notably, ChiE also contains residues (H224, C227, D228) arranged in a configuration resembling a catalytic triad (Fig

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