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doi: 10.1038/s41556-019-0440-0 158 ZhangZ.YangX.SongY

Figure 8 Discussion Betaine is a common additive in aquafeeds, with diets supplemented with betaine reported to improve growth performance and feed intake in various fish species such as allogynogenetic gibel carp ( Sander lucioperca ) ( Oreochromis niloticus ) ( It has been reported that fat accumulation was associated with impairment of hepatic one-carbon metabolism ( High fat diets in fish can readily cause liver injury, with the most obvious being increased lipid deposition and higher tissue lipid contents and, in the present study, the highest hepatic lipid content was observed in fish fed the HFD diet

33 ClinicalTrials (2021a)

Liver Dysfunction and Damage The livers role in processing fats, proteins, and balancing energy is disrupted by high Hcy, leading to fat buildup and inflammation