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doi:10.1038/jid.1993.78 29

consistent daily use may be helpful for steady antioxidant support

In general, folic acid in fortified products or taken with foods is 85/50 or 1.7 times more bioavailable than food folate

Interestingly, a link between DNA methylation changes and presence of ROS has been suggested with the finding that increased ROS leads to oxidation of 5mC into 5hmC [62], likely leading to changes in gene expression regulation