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Second, while this study proposes a mechanistic hypothesis based on proteomic findings, future studies using immunohistochemistry and cellular co-localization are needed to identify the cellular sources of CINC-3 and CNTF expression and clarify DPs cellular targets.Thirdly, this study is the absence of behavioral assessments such as von Frey test, weight bearing, or gait analysis, future studies will incorporate these approaches to further investigate the functional implications of the molecular changes observed

It is also important to ensure adequate folate levels through supplementation, if appropriate, once vitamin B12 supplementation has been commenced to avoid precipitating subacute combined degeneration of the spinal cord[2]

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A widely referenced review reports that GHK-Cu raises growth factors such as VEGF and is associated with larger follicles and better hair-transplant survival, though its author has a commercial affiliation, so it should be read as a mechanistic review rather than clinical proof (Pickart, 2008, DOI)