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Hirsutine alleviates ferroptosis in podocytes of db/db mice with diabetic nephropathy by downregulating the p53/GPX4 signaling pathway [149]

IVF-ET, in vitro fertilization-embryo transfer

Focused ultrasound-enhanced delivery of intranasally administered anti-programmed cell death-ligand 1 antibody to an intracranial murine glioma model

1,6 Some factors that likely contribute to cognitive decline include: Stem cell senescence Brain oxidative stress and mitochondrial dysfunction Neuroinflammation (inflammation in the brain) Circadian rhythm and metabolic disturbances Vascular dysfunction Abnormal protein accumulation in the brain Disordered homocysteine metabolism Changing hormone levels Epigenetic factorschanges in the way genes are expressed These same mechanisms also appear to contribute to dementia and neurodegenerative diseases like Alzheimer disease and Parkinson disease