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11 September 2023

Functional improvement (strength, range of motion) within 3-4 weeks

Consistent with the PAMPA measurements, the 1,8-diMQ analogue exhibited very low bi-directional transport in the Caco-2 cell assay (Table 5)

Standard RDA: 2.4 mcg for adults Senior-Specific Needs: Often higher than 2.4 mcg due to absorption issues Recommended Intake for Seniors: At least 2.4 mcg, potentially much higher with supplementation Why the Standard 2.4 mcg May Not Be Sufficient The standard 2.4 mcg dosage might not be enough for seniors for a few reasons: Decreased Stomach Acid: Needed for B12 release from food Atrophic Gastritis: A common condition in older adults that makes it hard to absorb B12 Medication Interference: Some medicines can also block B12 absorption For those over 50, its best to get most of their vitamin B12 from supplements and fortified foods