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These findings underscore the gap between experimental neuroprotection and clinically meaningful neurological outcomes (Table 3)

72 These findings suggest that subnormal ALP levels may be a useful diagnostic tool for HPP, that PLP levels may be useful in patients with a suspected diagnosis of HPP, for screening family members to detect possible heterozygotes, and to monitor response to therapy

3.2.4 Intestinal changes and bone health While we do not know of any study directly linking the effect of aging on gut barrier-to-bone signaling, the intestinal changes that occur with aging are associated with bone loss in other conditions

Similarly, inaccurate revenue and expenditure calculations based on data from a calendar year affected by SAHS billing activity may affect an ACO's revenue status and the amount of funds an ACO in a two-sided model must secure as a repayment mechanism, one of the program's important safeguards for protecting the Medicare Trust Funds