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102 Moreover, In Italian patients, the GSTM1 null genotype has been identified as a risk factor for late-onset Alzheimer's disease

They have been shown to inhibit tumor activity and growth in multiple preclinical studies modeling a range of cancer types (Jokovi 2025

However, their therapeutic outcomes are limited because of drug resistance due to the intracellular inactivation effect (Johnstone et al., 2016)

283 Thus, although validation in large patient cohorts is still pending, LIPC expression levels may constitute a biomarker that allows for the identification of patients who obtain a true clinical benefit from the administration of platinum-based chemotherapy