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Author(s): 1Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran 2Department of Physiology, Arak University of Medical Sciences, Arak, Iran 3Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran Zahedan Journal of Research in Medical Sciences:Vol

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2.13.3 Native mass spectrometry (nMS) Native mass spectrometry (nMS, which is a form of electrospray ionization mass spectrometry (ESI-MS)), being a relatively recent addition to the analytical toolbox of mass spectrometry, can be used to measure the size, stoichiometry, and interactions of macromolecules (such as proteins) in their native, folded state, thereby directly exploring the different conformational components in terms of geometry and structural compactness (Konijnenberg et al., 2015