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CsA is toxic to male genital function, and its toxicity can arise during treatment and has a dose-related manifestation, especially for patients under extended treatment regimens (Horoz et al., 2024)

Fortunately, add-on maintenance treatments like Nucala (mepolizumab) are approved by the Food and Drug Administration to treat eosinophilic asthma, a condition where an overproduction of a certain type of white blood cells called eosinophils cause inflammation in the airways and asthma attacks

Nature 626 , 874880 (2024)

This is important since imbalances in hormone biotransformation (e.g., inefficient methylation by catechol O -methyltransferases