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Section specific changes in permeability were also measured ex vivo by Ussing chambers which demonstrated that the ileum had the most dynamic changes

What we care about most, though, are interventional studies, where people are randomized to B12 so we can see what happens, and when we look at those, we find there is no increased fracture risk among those given B12

Warning: Supplementing with folate, even in some cases of high dietary folate intake, prevents or masks this folate trap process, but it does not remedy B12 deficiency or homocysteine accumulation (although it is possible that the latter may appear somewhat lower in the analysis than if you were not taking a diet high in folate, as folate is a cofactor that lowers homocysteine

A decrease in glutamine synthase was also discovered in epilepsy patients, suggesting that even after glutamate enters astrocytes, the clearance of glutamate may still be limited (Eid et al., 2019)