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This provides a mechanistic basis for portal pressure reduction in the context of IGF-1 deficiency-associated portal hypertension in cirrhosis, studied using mesenteric venous pressure catheters and microsphere-based portal blood flow quantification

These were further chelated by Mn ions for serving as a magnetic resonance imaging (MRI) contrast agent and PEGylated (HMONs-MnPpIX-PEG) [66]

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