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Goldstein AL, Hannappel E, Sosne G, Kleinman HK

(4)(5) Opioid receptors : Further research indicates that DSIP might indirectly affect opioid receptors in the brain

In symptomatic individuals, the diagnosis of WD relies on a high level of suspicion determined by a compatible medical history, physical examination, laboratory tests, liver biopsy, and imaging of the central nervous system [17]