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difficile infection Pneumonia Rebound acid hypersecretion on withdrawal Contraindications Allergy to omeprazole or other PPIs Severe liver disease (caution) Pregnancy category C (use with care) Avoid long-term unsupervised use Drug Interactions Warfarin ( bleeding risk) Phenytoin Diazepam Clopidogrel ( effectiveness) Methotrexate Ketoconazole, itraconazole ( absorption) Nursing Considerations / Patient Education Give before meals (preferably breakfast) Do not crush delayed-release capsules Monitor magnesium & B12 in long-term use Watch for GI infections or diarrhea Avoid alcohol & smoking (worsen reflux) Report persistent abdominal pain or bleeding Brands Losec Prilosec Omez Omecap To view or add a comment, sign in What is Paracetamol