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3.4.3 Mechanistic insights from preclinical modelsbarrier, immune, and neurotransmitter changes Rodent models of PTSD provide causal evidence that psychological trauma disrupts the MGBA, leading to microbiota alterations, compromised gut barrier integrity, immune activation and neurotransmitter imbalance

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Methods: PhEAST is a randomised, open-label, blinded-endpoint trial assessing pharyngeal electrical stimulation (PES) vs no PES