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Metabolic stability assay Each compound was diluted to a final concentration of 1 M in 100 mM phosphate buffer (pH 7.4) containing 0.5 mg ml 1 mouse liver microsomes, 1 mM NADPH regenerating system and 1 mM MgCl 2 and incubated at 37 C for 1 h

Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

LiHLimenitakisJPFuhrerTGeukingMBLawsonMAWyssMet alThe outer mucus layer hosts a distinct intestinal microbial niche