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Access this article Similar content being viewed by others Abbreviations AD: Alzheimers disease BBB: blood-brain barrier COMT: catechol-O-methyltransferase DA: dopamine agonists FDA: food and drug administration PD: Parkinson disease L-DOPA: levodopa LID: levodopa induced dyskinesias MAO-B: monoamine oxidative inhibitor NDRI: norepinephrine and dopamine reuptake inhibitor NMS: non-motor symptoms SN: substantia nigra SNRI: serotonin and norepinephrine reuptake inhibitor SSRI: selective serotonin reuptake inhibitor UPDRS: Unified Parkinson Disease Rating Scale UPR: unfolded protein response