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The vagus nerve is the super-highway of communication between the mind and the gut, and the gut and the mind

At the same time, iron-dependent lipoxygenase (LOX) catalyzes polyunsaturated fatty acids (PUFAs) to induce OS, which further alters the permeability of BBB (Iadecola and Anrather 2011)

doi: 10.1038/526312a 164 SmithM

Research suggests that the potential mechanism behind B12s ability to alleviate pain is through increasing nerve regeneration and decreasing ectopic nerve firing (which causes neuropathic pain)